发明名称 |
Detection of chromosomal inversions using non-repetitive nucleic acid probes |
摘要 |
A method for the identification of chromosomal inversions is described. Single-stranded sister chromatids are generated, for example by CO-FISH. A plurality of non-repetitive, labeled probes of relatively small size are hybridized to portions of only one of a pair of single-stranded sister chromatids. If no inversion exists, all of the probes will hybridize to a first chromatid. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. |
申请公布号 |
US8278050(B2) |
申请公布日期 |
2012.10.02 |
申请号 |
US20070375816 |
申请日期 |
2007.09.20 |
申请人 |
BAILEY SUSAN M.;RAY F. ANDREW;GOODWIN EDWIN H.;BEDFORD JOEL S.;CORNFORTH MICHAEL N.;COLORADO STATE UNIVERSITY RESEARCH FOUNDATION;BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BAILEY SUSAN M.;RAY F. ANDREW;GOODWIN EDWIN H.;BEDFORD JOEL S.;CORNFORTH MICHAEL N. |
分类号 |
C12Q1/68;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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