HIGH MOLECULAR WEIGHT POLYMER-BASED PRODRUGS

摘要

High molecular weight, water-soluble prodrugs of formula (I), wherein: D is a biologically active moiety; M is X or Q; X is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or sulfur; and R is a polyalkylene oxide, are disclosed. Methods of preparing the compounds as well as methods of treatment using the compounds are also disclosed.