摘要 |
New process for the regioselective enzymatic oxidation of bile acids, salts or derivatives thereof, such as cholic acid, chenodeoxycholic acid or cholic acid methyl ester, by NAD (P) +-dependent hydroxysteroid dehydrogenase (HSDH) in the presence of an alcohol dehydrogenase (ADH) and of methyl acetoacetate as a co- substrate for the regeneration of the cofactor NAD(P)+. |