ACRYLAMIDO DERIVATIVES USEFUL AS INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION

摘要

Disclosed is a compound of formula I (acrylamido derivatives), such as (E)-N-[3-(Benzyl-methyl-amino)-phenyl]-3-(3-hydroxy-4-methoxy-phenyl) acrylamide, (E)-N-[2-Chloro-3-(pyridin-4-ylmethoxy)-phenyl]-3-(3-hydroxy-4-methoxy-phenyl) acrylamide hydrochloride and (E)-3-(3-Hydroxy-4-methoxy-phenyl)-N-{ 3-[(pyridin-4-ylmethyl)-amino]-phenyl} acrylamide, for treatments of heart-related, brain-related and metabolic disorder-related diseases.