ARYL METHYL BENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

摘要

Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as described within the specification. Examples of compounds of formula (I) include: Rac-3-[trans-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]quinazolin-4(3H)-one; or 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methoxypyridin-3-yl)methyl]benzo[h[quinazolin-4(3H)-one. Further disclosed is a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I), and the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a disease or disorder medicated by the muscarinic M1 receptor, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.