发明名称 |
PROCESS FOR THE PREPARATION OF S-FLUOROMETHYL-6 ,9 -DIFLUORO-11 -HYDROXY-16 -METHYL-17 -PROPIONYLOXY-3-OXO-ANDROSTA-1,4-DIENE-17 -CARBOTHIOATE AND INTERMEDIATES |
摘要 |
<p>The present invention relates to a process for the preparation of steroidal 17²-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17²-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.</p> |
申请公布号 |
SI2044099(T1) |
申请公布日期 |
2012.09.28 |
申请号 |
SI20070030932T |
申请日期 |
2007.06.11 |
申请人 |
GENERICS (UK) LIMITED |
发明人 |
GORE VINAYAK G.;GADAKAR MAHESH;POKHARKAR K.;WAKCHURE V. |
分类号 |
|
主分类号 |
|
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|