摘要 |
A pharmaceutical multi-chamber container system 21 for mixing two or more ingredients of a pharmaceutical product for use in intravenous administration, comprises a first container 22 for containing a diluents liquid, a second container insert aseptically mounted into the top of the first container, the second container comprising a moulded container casing 2 for receiving a solid component 8, a resilient stopper 9 for sealing the open top of the moulded container casing 2, and a bottom disc 3 formed by a weakening rim in the bottom periphery of the moulded container casing 2. The bottom disc 3 is openable to allow mixing of the pre-filled solid component 8 with a diluents fluid of the first container 22 by introducing an intravenous spike 20 of an intravenous administration kit through the resilient stopper 9. The spike applies a pushing force on the bottom disc, by which force the weakening rim is broken and the second container is opened. |