The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
申请公布号
WO2012128868(A1)
申请公布日期
2012.09.27
申请号
WO2012US25252
申请日期
2012.02.15
申请人
IMMUNOGEN, INC.;LI, WEI;MILLER, MICHAEL;FISHKIN, NATHAN;CHARI, RAVI, V. J.
发明人
LI, WEI;MILLER, MICHAEL;FISHKIN, NATHAN;CHARI, RAVI, V. J.