CLASSIFICATION OF KINASE INHIBITORS USING NONLINEAR OPTICAL TECHNIQUES
摘要
A method is disclosed for classifying and distinguishing between type I and type II kinase inhibitors. The method involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes in kinase proteins obtained from known type I or type II inhibitors. The method further involves deducing the manner of binding of unknown inhibitors by comparison with the signal changes produced by known ligands. The method is also applied to comparing the conformational changes induced by the binding of generic and branded kinase inhibitor drugs to a target kinase.
申请公布号
WO2012129347(A1)
申请公布日期
2012.09.27
申请号
WO2012US30010
申请日期
2012.03.21
申请人
BIODESY, LLC;SALAFSKY, JOSHUA, S.;MCGUINNESS, RYAN