THE USE OF FENOTEROL AND FENOTEROL ANALOGUES IN THE TREATMENT OF GLIOBLASTOMAS AND ASTROCYTOMAS

摘要

This disclosure concerns the discovery of the use of fenoterol and (R, R)- and (R, S)- fenoterol analogues for the treatment of a tumor expressing a ß2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a ß2- adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.