发明名称 |
NOVEL ANTIMICROBIAL ACTIVITY OF CHICKEN NK-2 PEPTIDE AGAINST APICOMPLEXAN PROTOZOA |
摘要 |
NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry. |
申请公布号 |
WO2012129165(A2) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2012US29659 |
申请日期 |
2012.03.19 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE;LILLEHOJ, HYUN;LEE, SUNG HYEN;HONG, YEONG HO |
发明人 |
LILLEHOJ, HYUN;LEE, SUNG HYEN;HONG, YEONG HO |
分类号 |
C07K14/47;A61K38/17;A61P31/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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