| 发明名称 |
PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS |
| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a compound which is 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid or a pharmaceutically acceptable salt thereof. The invention also relates to use thereof to inhibit 11HSD1 (11--hydroxysteroid-dehydrogenase type 1), synthesis method thereof and a pharmaceutical composition containing said compounds. ^ EFFECT: improved method. ^ 12 cl, 1 tbl, 47 ex |
| 申请公布号 |
RU2462456(C2) |
申请公布日期 |
2012.09.27 |
| 申请号 |
RU20090133259 |
申请日期 |
2008.02.11 |
| 申请人 |
ASTRAZENEKA AB |
发明人 |
PAKER MARTIN DZHON;SKOTT DZHEJMS STJUART;STOKER EHNDRJU;UITTAMOR POL ROBERT OUEHN |
| 分类号 |
A61K31/415;A61K31/4155;A61P3/00;C07D231/14;C07D231/18;C07D403/06;C07D405/12 |
主分类号 |
A61K31/415 |
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