AUTOMATIC VOLUMETRIC ANALYSIS AND 3D REGISTRATION OF CROSS SECTIONAL OCT IMAGES OF A STENT IN A BODY VESSEL

摘要

A computer based method of automated volumetric stent analysis and OCT pullbacks (datasets) registration in time comprising computer based analysing of multiple images from in- vivo acquired cross sectional OCT images, recorded by an OCT catheter pullback at baseline (freshly implanted device) and at any time point thereafter, of long vessel segments of stent formed by strut from bars in a body vessel (e.g. vascular) the method comprising automatic distance identification and measurement of the separate surfaces zones of said implant device to vessel wall (apposition) and/or covering neointima (corresponding to vessel healing after implantation of the implant device) and the method being characterised in that 1 ) individual stent struts coverage and apposition and further areas and volumes of separate surfaces zones of a) said implant device to vessel wall (apposition) or b) of neointima coverage are volumetric measured by clustering of neointima coverage according to their spatial 3D location through analysis of equally spaced consecutive OCT cross sectional images or by automatically clustering uncovered (malapposition) struts according to their 3D spatial position through consecutive cross sectional images and 2) registration of intravascular OCT pullbacks recordings (IV-OCT datasets) of points of long vessel segments of transluminal implant device but at different time points of the implantation period comprising a) 3D alignment by rotation and translation and b) refinement of the registration by a registration algorithm (e.g. Interactive closest point (ICP)) and iteratively at a multi-resolution.