发明名称 |
BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS |
摘要 |
<p>Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is CH2CF3 or CH2CH2CF3; R2 is CH2CF3, CH2CH2CF3, or CH2CH2CH2CF3; R3 is H or CH3; each Ra is independently F, Cl, -CN, -OCH3, and/or NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.</p> |
申请公布号 |
WO2012129353(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2012US30021 |
申请日期 |
2012.03.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;QUESNELLE, CLAUDE;KIM, SOONG-HOON;LEE, FRANCIS;GAVAI, ASHVINIKUMAR |
发明人 |
QUESNELLE, CLAUDE;KIM, SOONG-HOON;LEE, FRANCIS;GAVAI, ASHVINIKUMAR |
分类号 |
C07D243/24;A61K31/5513;A61P35/00 |
主分类号 |
C07D243/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|