发明名称 |
METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY |
摘要 |
The present invention provides methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring genetically modified tumor specific CD8+ T cells in the presence of tumor-specific, subset specific genetically modified CD4+ T cells, wherein the CD4+ T cells confer and/or augment a CD8+ T cells ability to sustain anti-tumor reactivity and increase and/or maximize tumor-specific proliferation of the tumor-specific CD8+ T cells of interest. Pharmaceutical formulations produced by the method, and methods of using the same, are also described. |
申请公布号 |
WO2012129514(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2012US30388 |
申请日期 |
2012.03.23 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER;RIDDELL, STANLEY, R.;HUDECEK, MICHAEL |
发明人 |
RIDDELL, STANLEY, R.;HUDECEK, MICHAEL |
分类号 |
C12N5/0783;A61P35/00;C07K14/705;C07K16/28;C07K16/30 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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