| 发明名称 |
ACTIVATORS OF HUMAN PYRUVATE KINASE |
| 摘要 |
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
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| 申请公布号 |
US2012245141(A1) |
申请公布日期 |
2012.09.27 |
| 申请号 |
US201213433656 |
申请日期 |
2012.03.29 |
| 申请人 |
THOMAS CRAIG J.;AULD DOUGLAS S.;INGLESE JAMES;SKOUMBOURDIS AMANDA P.;JIANG JIAN-KANG;BOXER MATTHEW B.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES |
发明人 |
THOMAS CRAIG J.;AULD DOUGLAS S.;INGLESE JAMES;SKOUMBOURDIS AMANDA P.;JIANG JIAN-KANG;BOXER MATTHEW B. |
| 分类号 |
A61K31/496;A61K31/357;A61K31/397;A61K31/4025;A61K31/453;A61K31/4704;A61K31/495;A61K31/5025;A61K31/551;A61P35/00;A61P35/02;C07D215/22;C07D243/08;C07D295/26;C07D319/18;C07D405/12;C07D405/14;C07D495/14 |
主分类号 |
A61K31/496 |
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