发明名称 BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE
摘要 Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
申请公布号 US2012245144(A1) 申请公布日期 2012.09.27
申请号 US201213424500 申请日期 2012.03.20
申请人 HEFFRON TIMOTHY;SAFINA BRIAN;STABEN STEVEN;SUTHERLIN DANIEL P.;WEI BINQING;ELLIOTT RICHARD;HEALD ROBERT;SEWARD EILEEN M.;GANCIA EMANUELA;WASKOWYCZ BOHDAN;GENENTECH, INC. 发明人 HEFFRON TIMOTHY;SAFINA BRIAN;STABEN STEVEN;SUTHERLIN DANIEL P.;WEI BINQING;ELLIOTT RICHARD;HEALD ROBERT;SEWARD EILEEN M.;GANCIA EMANUELA;WASKOWYCZ BOHDAN
分类号 A61K31/553;A61P1/00;A61P1/04;A61P3/00;A61P5/00;A61P7/00;A61P9/00;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;A61P37/06;A61P37/08;A61P43/00;C07D498/04;C07D498/14 主分类号 A61K31/553
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