COMPOSITIONS AND METHODS FOR INCREASING ERYTHROPOIETIN (EPO) PRODUCTION

摘要

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting one or more EGLN genes, EGLN1, EGLN2 and/or EGLN3 and methods of using such dsRNA compositions to inhibit expression ofthese genes. An exemplary composition comprises at least one double-stranded ribonucleic acid (dsRNA) for inhibiting expression ofEGLNI, wherein said dsRNA comprises a sense strand and an antisense strand, wherein the sense strand comprises at least contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of sequences listed in Tables 2A-F and 6A-C and the antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence of sequences listed in Tables 2A-F and 6A-C.