发明名称 |
BISPECIFIC BINDING AGENTS TARGETING IGF-1R AND ERBB3 SIGNALLING AND USES THEREOF |
摘要 |
Disclosed are bispecific binding agents that specifically target both of the IGF-1 and the ErbB intracellular signaling pathways. For example, bispecific binding agents that comprise an anti-IGF-1R antibody and an anti-ErbB3 antibody connected by a linker are described herein. These bispecific agents are capable of antagonizing signal transduction by both of the IGF-1 and the ErbB signaling pathways and are useful in inhibiting the proliferation of tumor cells whose growth involves the signaling activity of both pathways. |
申请公布号 |
US2012244163(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
US201213443660 |
申请日期 |
2012.04.10 |
申请人 |
SCHOEBERL BIRGIT;NIELSEN ULRIK;KUDLA ARTHUR J.;MURUGANANDAM ARUMUGAM;BUCKLER DAVID;LUGOVSKOY ALEXEY ALEXANDROVICH;FITZGERALD JONATHAN BASIL;XU LIHUI;KOHLI NEERAJ;DYAX CORP.;MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
SCHOEBERL BIRGIT;NIELSEN ULRIK;KUDLA ARTHUR J.;MURUGANANDAM ARUMUGAM;BUCKLER DAVID;LUGOVSKOY ALEXEY ALEXANDROVICH;FITZGERALD JONATHAN BASIL;XU LIHUI;KOHLI NEERAJ |
分类号 |
A61K39/395;A61K38/02;A61N5/10;A61P35/00;C07K19/00;C12N5/09;C12N5/10;C12N15/62;C12P21/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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