ANTI-MOUSE AGGRUS MONOCLONAL ANTIBODY

摘要

The invention of the application provides a monoclonal antibody or functional fragment thereof that is capable of recognizing epitopes of Aggrus consisting of the amino acid sequence represented by Sequence No. 1, 3, or 4, and a monoclonal antibody or functional fragment thereof that is produced from a hybridoma of deposit No. FERM BP-11446, FERM BP-11447, FERM BP-11448, or FERM BP-11449. The invention provides the hybridoma and further provides an Aggrus-CLEC-2 bond inhibitor and a pharmaceutical composition for the prevention of platelet aggregation or cancer metastasis and for the treatment of tumors or thrombosis that comprises the monoclonal antibody or functional fragment thereof.