BIOMARKERS FOR PREDICTING THE RECURRENCE OF COLORECTAL CANCER METASTASIS
摘要
<p>The present invention includes biomarkers and methods for predicting recurrence-free survival and determination of risk for colorectal liver metastasis (LM) by determining a level of microsatellite instability at tetranucleotide repeats (EMAST) and at mono- and a dinucleotide repeat loci (MSI-L) or a SMARCA2R-LOH in colorectal cancer (CRC) patients. Results obtained indicate that stage II and III patients with MSI-M had a shorter recurrence-free survival than the rest of patients with high levels of MSI (MSI-H) or with highly stable microsatellites, and that MSI-M is an independent predictor for recurrent distant metastasis in primary stage II and III CRCs. It was found that SMARCA2R-LOR and MSI-M are found in stage IV primary CRC and LM tissues.</p>
申请公布号
WO2012129092(A1)
申请公布日期
2012.09.27
申请号
WO2012US29441
申请日期
2012.03.16
申请人
BAYLOR RESEARCH INSTITUTE;KOI, MINORU;BOLAND, C., RICHARD