发明名称 |
COMBINATION MEDICINE FOR TREATMENT OF DEPRESSION |
摘要 |
<p>The present invention provides a combination medicine for treatment of depression, comprising a combination of (A1) an antidepressant and either (B1) a dopamine D1 receptor agonist or (C1) a dopamine D1 receptor antagonist; and a method for screening for an antidepressant that in combination with a dopamine D1 receptor agonist provides an improvement in treatment of depression, the method comprising the steps of: administering, to a mammal, (A2) a compound having an antidepressant action and (B1)a dopamine D1 receptor agonist, and detecting a greater increase in depression-related gene expression, dopamine D1 receptor expression and/or dopamine D1 receptor signaling in comparison with the case where (A2) the compound having an antidepressant action or (B1) the dopamine D1 receptor agonist is administered.</p> |
申请公布号 |
WO2012127871(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
WO2012JP01996 |
申请日期 |
2012.03.22 |
申请人 |
KURUME UNIVERSITY;NIPPON MEDICAL SCHOOL FOUNDATION;SCHOOL JURIDICAL PERSON FUJITA EDUCATIONAL INSTITUTION;THE ROCKEFELLER UNIVERSITY;NISHI, AKINORI;KOBAYASHI, KATSUNORI;MIYAKAWA, TSUYOSHI;GREENGARD, PAUL |
发明人 |
NISHI, AKINORI;KOBAYASHI, KATSUNORI;MIYAKAWA, TSUYOSHI;GREENGARD, PAUL |
分类号 |
A61K45/06;A61K31/137;A61K31/138;A61K31/343;A61K31/4525;A61K31/55;G01N33/15;G01N33/50 |
主分类号 |
A61K45/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|