发明名称 |
Apoptotic cell-mediated transfection of mammalian cells with interfering RNA |
摘要 |
<p>Mammalian host cells for use in a cell-mediated transfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of down-regulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs down-regulates the expression of the target gene in living cells.</p> |
申请公布号 |
EP2489729(A3) |
申请公布日期 |
2012.09.26 |
申请号 |
EP20120159304 |
申请日期 |
2007.09.28 |
申请人 |
LOMA LINDA UNIVERSITY |
发明人 |
LI, FENGCHUN;ESCHER, ALAN P. |
分类号 |
C12N5/10;A61K31/713;A61P37/06;C12N15/11;C12N15/113 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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