发明名称 |
STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF |
摘要 |
The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders. |
申请公布号 |
KR20120106788(A) |
申请公布日期 |
2012.09.26 |
申请号 |
KR20127017676 |
申请日期 |
2010.11.05 |
申请人 |
ALLERGAN, INC. |
发明人 |
BURK ROBERT M.;IM WHA BIN |
分类号 |
A61K31/4025;A61K9/08;A61K31/4436;A61K47/12 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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