SEQUENCES FOR REGULATING A HYPOXIA-INDUCIBLE GENE EXPRESSION AND USES THEREOF

摘要

PURPOSE: A recombinant expression vector containing gene expression regulatory sequences is provided to treat airway inflammation-related diseases. CONSTITUTION: A gene expression regulatory sequence contains a MUC5AC(mucin 5AC) promoter containing a nucleotide sequence of sequence number 1. A hypoxia-inducible gene recombinant expression vector contains: the promoter; and an operatively linked expression subject substance-coding nucleotide sequence. The MUC5AC promoter contains hypoxia-response elements. [Reference numerals] (AA) Relatively increasing multiple for basic vector