New multi-therapy administration patterns suitable for treating persons affected by human immunodeficiency virus (HIV)

摘要

Pharmaceutical composition comprises three or four active ingredients comprising: a nucleoside reverse transcriptase inhibitor (NRTI) comprising emtricitabine and lamivudine; another nucleoside or nucleotide reverse transcriptase inhibitor (NRTI) comprising didanosine, abacavir and tenofovir; and the combination of ritonavir with protease inhibitor (PI) comprising lopinavir, fosamprenavir, atazanavir and darunavir, or a non nucleoside reverse transcriptase inhibitors (NNRTI) comprising efavirenz and etravirine, for a daily administration of one to four days per week to the human. An independent claim is included for a pharmaceutical product containing the nucleoside reverse transcriptase inhibitor comprising lamivudine and emtricitabine; another nucleoside or nucleotide reverse transcriptase inhibitor (NRTI) comprising didanosine, abacavir and tenofovir, and the combination of ritonavir with protease inhibitor comprising lopinavir, fosamprenavir, atazanavir and darunavir, or a non nucleoside reverse transcriptase inhibitors comprising efavirenz and etravirine, as a combination product for daily simultaneous, separate or staggered administration for one to four days per week in the treatment of HIV in humans. ACTIVITY : Anti-HIV. MECHANISM OF ACTION : Nucleoside reverse transcriptase inhibitor.