摘要 |
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:
In the compounds of Formula I, B or R 2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a -CH 2 -. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
ALI, AMJAD;NAPOLITANO, JOANN, M.;DENG, QIAOLIN;LU, ZHIJIAN;SINCLAIR, PETER, J.;TAYLOR, GAYLE, E.;THOMPSON, CHRISTOPHER, F.;QURAISHI, NAZIA;SMITH, CAMERON, J.;HUNT, JULIANNE, A.;DOWST, ADRIAN, A.;CHEN, YI-HENG;LI, HONG |