| 摘要 |
There is disclosed a method of modifying red blood cells, comprising:
(i) suspending group B or group AB erythrocytes in a buffer solution having a neutral pH,
(ii) incubating the erythrocytes of step(i) with an enzyme having ±-galactosidase activity, and
(iii) isolating the converted erythrocytes of step(ii) from the enzyme and the enzymatically-cleaved immunodominant galactose residues,
thereby cleaving the branched immunodominant B epitopes on the group B or group AB erythrocyte as determined by serological typing or hemagglutination assays. |
