发明名称 |
PHARMACEUTICAL COMPOSITION FOR TREATING AGING-RELATED DISEASES COMPRISING INHIBITOR OF PROGERIN AND SCREENING METHOD THEREOF |
摘要 |
PURPOSE: A pharmaceutical composition containing a progerin expression inhibitor is provided to effectively treat or prevent disease caused by progerin overexpression. CONSTITUTION: A pharmaceutical composition for treating aging-related diseases contains a progerin expression inhibitor as an active ingredient. The inhibitor is pVHP(Hippel-Lindau tumor suppressor protein)-progerin binding promoter; or RNA interfering-mediated RNA of antisense RNA, RNAi, shRNA, or siRNA. A method for screening a therapeutic agent for treating aging-related diseases comprises: a step of cultuirng pVHP, progerin, and candidate drugs; and a step of selecting analyzing progerin expression level.
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申请公布号 |
KR20120106286(A) |
申请公布日期 |
2012.09.26 |
申请号 |
KR20110024308 |
申请日期 |
2011.03.18 |
申请人 |
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION |
发明人 |
PARK, BUM JOON;HA, NAM CHUL |
分类号 |
A61K31/70;A61K31/7088;A61K38/16;A61P35/00 |
主分类号 |
A61K31/70 |
代理机构 |
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