发明名称 |
HUMAN AND MOUSE TREK-1 POTASSIUM CHANNEL PROTEIN AND THEIR USE |
摘要 |
Human and mouse TREK-1 potassium transport proteins are disclosed as well as a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia and analgesia in a mammal upon inhalation, in a method comprising (a) contacting the test substance with a mammalian potassium transport protein, wherein said potassium transport protein exhibits outward-going potassium rectification; and (b) determining the potassium transport activity of the potassium transport protein, wherein an activation of potassium transport is indicative of the test substance having anesthetic properties.
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申请公布号 |
CA2359761(C) |
申请公布日期 |
2012.09.25 |
申请号 |
CA20002359761 |
申请日期 |
2000.02.11 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
LAZDUNSKI, MICHEL;HONORE, ERIC;LESAGE, FLORIAN;ROMEY, GEORGES;PATEL, AMANDA J. |
分类号 |
C12N15/12;G01N33/50;C07K14/47;C07K14/705;C12N15/09;C12Q1/02;C12Q1/68;C12R1/91;G01N33/15 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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