发明名称 |
Viral variants |
摘要 |
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. |
申请公布号 |
US8273527(B2) |
申请公布日期 |
2012.09.25 |
申请号 |
US20070905904 |
申请日期 |
2007.10.05 |
申请人 |
BARTHOLOMEUSZ ANGELINE;LITTLEJOHN MARGARET;AYRES ANNA;LOCARNINI STEPHEN;MELBOURNE HEALTH |
发明人 |
BARTHOLOMEUSZ ANGELINE;LITTLEJOHN MARGARET;AYRES ANNA;LOCARNINI STEPHEN |
分类号 |
C12Q1/70;A61K39/00;A61K39/29;C07K14/02;C07K16/08;C12N7/00;C12N7/01;C12N15/13;C12N15/36;C12Q1/68 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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