发明名称 |
ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF |
摘要 |
Compound derivatives of aconitine are provided, in particular derivatives that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier. The subject compounds are useful in treatments, including treatments to modulate neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the aconitine derivatives. |
申请公布号 |
US2012238526(A1) |
申请公布日期 |
2012.09.20 |
申请号 |
US201213421809 |
申请日期 |
2012.03.15 |
申请人 |
BOIS JUSTIN DU;ANDRESEN BRIAN M.;MENARD FREDERIC |
发明人 |
BOIS JUSTIN DU;ANDRESEN BRIAN M.;MENARD FREDERIC |
分类号 |
A61K31/439;A61K31/695;A61P1/00;A61P9/06;A61P13/10;A61P17/00;A61P19/02;A61P21/00;A61P21/02;A61P25/00;A61P25/06;A61P25/08;A61P29/00;A61P35/00;C07D221/22;C07D405/12;C07F7/18 |
主分类号 |
A61K31/439 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|