发明名称 |
NANOWIRE FIELD-EFFECT TRANSISTOR BIOSENSOR WITH IMPROVED SENSITIVITY |
摘要 |
The present invention is directed to a multiwire nanowire field effect transistor (nwFET) device for the measurement. The device includes a sensing nanowire having a first end and a second end and a nanowire FET having a first end and a second end, wherein the first end of the sensing nanowire is connected to the nanowire FET to form a node. Additionally, the first end of the nanowire FET is connected to a source electrode, the second end of the nanowire FET is connected to a drain electrode, and the second end of the sensing nanowire is connected to a base electrode. The sensing nanowire is derivatized with a plurality of immobilized capture probes that are specific for a target(s) of interest. The device is used to detect biomolecules or to detect the change in the ionic environment of a sample. In a further embodiment, the sensing nanowire is derivatized with amino, carboxyl or hydroxyl groups. Upon a change in ionic environment, or binding of a molecule to the sensing nanowire, the sensing nanowire current (I B ) fluctuates. This fluctuation is amplified and readout as the nanowire FET drain current (I D ). Accordingly, the present invention provides for label-free detection of biomolecules and may find use as a point-of-care diagnostic device. |
申请公布号 |
WO2012075445(A3) |
申请公布日期 |
2012.09.20 |
申请号 |
WO2011US63157 |
申请日期 |
2011.12.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CHUI, CHI ON;SHIN, KYEONG-SIK |
发明人 |
CHUI, CHI ON;SHIN, KYEONG-SIK |
分类号 |
G01N27/414;C12Q1/68;G01N33/483 |
主分类号 |
G01N27/414 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|