发明名称 |
NUCLEIC ACIDS ENCODING A MUT-T DOMAIN-CONTAINING POLYPEPTIDE |
摘要 |
The invention pertains to nucleic acids encoding a mutT domain-containing polypeptide, including fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics involving the foregoing polypeptide and nucleic acids and agents that bind the foregoing polypeptide and nucleic acids. The invention also pertains to the identification of a novel mutT domain in human TrpC7, a polypeptide previously described as a putative calcium ion channel. Accordingly, the invention also pertains to methods and compositions for identifying agents useful in modulating mutT domain-mediated calcium or other ion transport in cells expressing a polypeptide comprising a mutT domain and a calcium or other ion channel. |
申请公布号 |
US2012237493(A1) |
申请公布日期 |
2012.09.20 |
申请号 |
US201213416854 |
申请日期 |
2012.03.09 |
申请人 |
SCHARENBERG ANDREW M.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
SCHARENBERG ANDREW M. |
分类号 |
A61K38/46;A61K31/7088;A61K48/00;C07K14/705;C07K16/40;C12N1/21;C12N9/14;C12N15/12;C12N15/55;C12N15/70;C12Q1/34;C12Q1/68;G01N33/53;G01N33/573 |
主分类号 |
A61K38/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|