发明名称 |
THE DESIGN OF HYDROLYTICALLY RELEASABLE PRODRUGS FOR SUSTAINED RELEASE NANOPARTICLE FORMULATIONS |
摘要 |
A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step. |
申请公布号 |
WO2012092339(A3) |
申请公布日期 |
2012.09.20 |
申请号 |
WO2011US67531 |
申请日期 |
2011.12.28 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA;ALFERIEV, IVAN;CHORNY, MICHAEL;LEVY, ROBERT, J. |
发明人 |
ALFERIEV, IVAN;CHORNY, MICHAEL;LEVY, ROBERT, J. |
分类号 |
A61K31/74;A61K9/14;A61K9/22 |
主分类号 |
A61K31/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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