CLEAVAGE INHIBITORS OF TRANSFORMING GROWTH FACTOR BETA TYPE I RECEPTOR AND USES THEREOF IN CANCER THERAPY

摘要

Disclosed herein are methods to inhibit cleavage of a type I receptor of transforming growth factor beta (?ßRI) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of ?ßRI and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of ?ßRI, which is a product of ?ßRI cleavage.