摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel method of producing one crystalline polymorphous form of a hydrogen halide of an organic amine, preferably in comparison with another crystalline polymorphous form of a hydrogen halide of an organic amine. The method involves adding trialkylsilyl halide to an organic amine in a solvent, where the trialkylsilyl halide is added in conditions in which one polymorphous form crystallises preferably in comparison with another polymorphous, and where the organic amine is in form of a free base or acid addition salt. If the organic amine is in form of an acid addition salt, the conjugated acid of the acid addition salt is weaker than the hydrogen halide acid, and the solvent is aprotic, and if the organic amine is in form of a free base, then it dissolves in the aprotic solvent and the trialkylsilyl halide is added to the aprotic solvent. ^ EFFECT: organic amine is a pharmaceutically active compound which contains a primary, a secondary, a tertiary or a quaternary amine group. ^ 6 cl, 66 dwg, 30 ex |