New synthesis of substituted hydroxymethyl phenols

摘要

The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-l-phenylpropyl)-4-(hydroxymethyl) phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formula (II) with a mixture of a Grignard initiator and Mg in a solvent; b) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a) , and reacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III) wherein A is a C-C alkyl, and the further reacting the compound of formula (III) in a known manner to obtain the desired end product.