发明名称 |
Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
摘要 |
<p>The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3- reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.</p> |
申请公布号 |
AU2011223782(A1) |
申请公布日期 |
2012.09.20 |
申请号 |
AU20110223782 |
申请日期 |
2011.03.01 |
申请人 |
MACROGENICS, INC. |
发明人 |
LOO, DERYK T.;HUANG, LING;MOORE, PAUL A.;CHEN, FRANCINE ZHIFEN;JOHNSON, LESLIE S. |
分类号 |
C07K16/00;A61K39/00;A61K39/395 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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