Antiseptic solutions comprising chlorhexidine or its salt and an anionic dye and their preparation

摘要

The present invention relates to a stable antiseptic solution comprising: at least one di(4-chloro-phenyldiguanido) derivative or a pharmaceutically acceptable salt thereof, wherein said di(4-chloro-phenyldiguanido) derivative or a pharmaceutically acceptable salt thereof is a compound of formula (I) or a pharmaceutically acceptable salt thereof;
and an at least one anionic dye, wherein the anionic dye or the total amount of anionic dyes present in the antiseptic solution are in an amount sufficient to stain a patient's skin or surgical field before surgery, when applied; wherein the antiseptic solution is essentially free of any cationic excipient.