发明名称 |
ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES |
摘要 |
<p>The present invention features, inter alia, compositions and methods for the treatment of cancer and infectious disease. The compositions include engineered proteins that specifically bind a metal chelate and may be bispecific. For example, the engineered proteins may bind (a) a target (e.g., a cellular protein) on a cancerous cell or a pathogen and (b) a metal chelate comprising DOTA, or an active variant thereof, and a metal ion such as a radionuclide. By virtue of the multiple binding sites, the engineered protein effectively delivers a metal chelate to a cell one wishes to destroy.</p> |
申请公布号 |
EP2403530(A4) |
申请公布日期 |
2012.09.19 |
申请号 |
EP20100746976 |
申请日期 |
2010.03.01 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
DAVIS, KELLY, J.;WITTRUP, K., DANE |
分类号 |
A61K39/395;A61P31/00;A61P35/00;C07K16/00;C12N5/073;C12N15/13;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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