发明名称 |
Methods and compositions for the prevention and treatment of anemia |
摘要 |
Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analogs. |
申请公布号 |
US8268588(B2) |
申请公布日期 |
2012.09.18 |
申请号 |
US201113168913 |
申请日期 |
2011.06.24 |
申请人 |
EGRIE JOAN C.;ELLIOTT STEVEN G.;BROWNE JEFFREY K.;SITNEY KAREN C.;AMGEN INC. |
发明人 |
EGRIE JOAN C.;ELLIOTT STEVEN G.;BROWNE JEFFREY K.;SITNEY KAREN C. |
分类号 |
C12N15/00;C07K14/505;C12N1/00;C12N5/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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