发明名称 2,3-diaryl- or heteroaryl-substituted 1,1,1-trifluoro-2-hydroxypropyl compounds
摘要 The present invention relates to compounds of formula I wherein R1a to R1c, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
申请公布号 US8268820(B2) 申请公布日期 2012.09.18
申请号 US20100727271 申请日期 2010.03.19
申请人 HUNZIKER DANIEL;LERNER CHRISITAN;MUELLER WERNER;SANDER ULRIKE OBST;PFLIEGER PHILIPPE;WALDMEIER PIUS;HOFFMANN-LA ROCHE INC. 发明人 HUNZIKER DANIEL;LERNER CHRISITAN;MUELLER WERNER;SANDER ULRIKE OBST;PFLIEGER PHILIPPE;WALDMEIER PIUS
分类号 C07D265/36;A61K31/536 主分类号 C07D265/36
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