发明名称 |
Low density lipoprotein receptor-mediated siRNA delivery |
摘要 |
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
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申请公布号 |
US8268798(B2) |
申请公布日期 |
2012.09.18 |
申请号 |
US201113150317 |
申请日期 |
2011.06.01 |
申请人 |
ALCON RESEARCH, LTD. |
发明人 |
CHATTERTON JON E. |
分类号 |
A61K48/00;C07H21/02;C07H21/04;C07K5/00;C12N15/11 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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