发明名称 |
Composition and method for preparing plasminogen |
摘要 |
Disclosed is both a method for preparing a plasminogen and a method for preparing a reversibly inactive acidified plasmin by activating the plasminogen. The prepared plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The prepared plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
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申请公布号 |
US8268782(B2) |
申请公布日期 |
2012.09.18 |
申请号 |
US20090399438 |
申请日期 |
2009.03.06 |
申请人 |
REBBEOR JAMES F.;STRAUSS JONATHAN S.;YUZIUK JEFFREY A.;GRIFOLS THERAPEUTICS INC. |
发明人 |
REBBEOR JAMES F.;STRAUSS JONATHAN S.;YUZIUK JEFFREY A. |
分类号 |
A61K38/00;A61K38/48;A61K47/02;A61K47/12;A61K47/18;A61K47/26;C07K1/18;C07K14/435;C12N9/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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