摘要 |
Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot. |
申请人 |
JOHNS HOPKINS UNIVERSITY;HWANG, CHAO-WEI;TOMEY, HALA, J.;RESAR, JON, R.;MATTESON, ROBERT, C., III;COLES, GEORGE, L., JR.;BENKOSKI, JASON, J.;TREXLER, MORGANA, M. |
发明人 |
HWANG, CHAO-WEI;TOMEY, HALA, J.;RESAR, JON, R.;MATTESON, ROBERT, C., III;COLES, GEORGE, L., JR.;BENKOSKI, JASON, J.;TREXLER, MORGANA, M. |