发明名称 SCREENING ASSAYS USING STEM CELLS AND STEM CELL-DERIVED NEURONS FROM MOUSE MODELS OF ALZHEIMER'S DISEASE
摘要 Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid ß-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens.
申请公布号 WO2012122405(A2) 申请公布日期 2012.09.13
申请号 WO2012US28345 申请日期 2012.03.08
申请人 THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;KIM, TAE-WAN;MCINTIRE, LAURA, BETH JOHNSON;LANDMAN, NATALIE;FINAN, GINA 发明人 KIM, TAE-WAN;MCINTIRE, LAURA, BETH JOHNSON;LANDMAN, NATALIE;FINAN, GINA
分类号 G06Q40/00 主分类号 G06Q40/00
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