发明名称 |
ANTI CD4 ANTIBODIES TO PREVENT IN PARTICULAR GRAFT -VERSUS - HOST - DISEASE (GVHD) |
摘要 |
The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses. The invention further relates to the modification of antibodies reactive to the CD4 human leukocyte antigen to provide anti-CD4 antibodies that have a reduced number of potential T-cell epitopes but retain the ability to bind to CD4, such as to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains. Preferably, the specificity and mode of action of the anti-CD4 antibodies are not affected by the modification(s). |
申请公布号 |
WO2012072268(A3) |
申请公布日期 |
2012.09.13 |
申请号 |
WO2011EP06060 |
申请日期 |
2011.12.02 |
申请人 |
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWADTEN FORSCHUNG E.V.;UNIVERSITAET LEIPZIG;FRICKE, STEPHAN;EMMRICH, FRANK;HILGER, NADJA |
发明人 |
FRICKE, STEPHAN;EMMRICH, FRANK;HILGER, NADJA |
分类号 |
A61K35/28;A61P37/06;C07K16/28;C12N5/00 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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