发明名称 |
PROCESS FOR THE PREPARATION OF GADOBENATE DIMEGLUMINE COMPLEX IN A SOLID FORM |
摘要 |
The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions. |
申请公布号 |
KR20120101462(A) |
申请公布日期 |
2012.09.13 |
申请号 |
KR20127015988 |
申请日期 |
2010.11.23 |
申请人 |
BRACCO IMAGING S.P.A. |
发明人 |
ANELLI PIER LUCIO;LATTUADA LUCIANO;FRETTA ROBERTA;FERRIGATO AURELIA;MOROSINI PIER FRANCESCO;CERAGIOLI SILVIA;UGGERI FULVIO |
分类号 |
C07C227/38;A61K9/08;A61K49/00;C07C229/22 |
主分类号 |
C07C227/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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