CONTROLLED-RELEASE COMPOSITION CONTAINING OPIOID AGONIST AND ANTAGONIST

摘要

PROBLEM TO BE SOLVED: To urge approval of a patient, and thereby to increase effects of opioid agonist treatment of a patient to be treated with the opioid agonist.

SOLUTION: Controlled-release dosage forms containing an opioid agonist; an opioid antagonist; and a controlled release material release during a dosing interval an analgesic or sub-analgesic amount of the opioid agonist along with an amount of the opioid antagonist effective to attenuate a side effect of the opioid agonist. The dosage form provides analgesia for at least about 8 hours when administered to human patients. In other embodiments, the dose of antagonist released during the dosing interval enhances the analgesic potency of the opioid agonist.

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